Some numerical questions in mathematical modeling of drug-induced gene induction

  • Date:
  • Time: 14:00 - 15:30
  • Address:
    Sokolovská 83, Praha
  • Room: K3
  • Speaker: Jurjen Tebbens

The talk consists of an introduction in the most popular mathematical models used to describe the action of drug-activated DNA transcription factors. Starting from the standard types of relevant kinetic reaction equations, it presents corresponding systems of ODEs and PDEs and discusses their numerical solution. It is planned to address in particular numerical integration, sensitivity, identifiability and observability of parameters and quasi-steady-state assumptions.